Adenosine and IFN-α synergistically increase IFN-γ production of human NK cells
نویسندگان
چکیده
منابع مشابه
Lipopolysaccharide induces IFN-γ production in human NK cells
Natural killer (NK) cells have been shown to play a regulatory role in sepsis. According to the current view, NK cells become activated via macrophages or dendritic cells primed by lipopolysaccharide (LPS). Recently, TLR4 gene expression was detected in human NK cells suggesting the possibility of a direct action of LPS on NK cells. In this study, effects of LPS on NK cell cytokine production a...
متن کاملrecombinant lpg3 stimulates ifn-γ and tnf-α secretion by human nk cells
background: natural killer (nk) cells play an important role in early stages of innate immune responses against viral and tumoral attacks. activation of nk cells by leishmaniasis results in secretion of cytokines such as interferon (ifn)-γ and tumor necrosis factor (tnf)-α, which enhances the phagocytosis and clearance of parasite. lipophosphoglycan 3 (lpg3), the leishmania homologous with grp...
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BACKGROUND Natural killer (NK) cells play an important role in early stages of innate immune responses against viral and tumoral attacks. Activation of NK cells by leishmaniasis results in secretion of cytokines such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α, which enhance the phagocytosis and clearance of parasite. Lipophosphoglycan 3 (LPG3), the Leishmania homologous with GRP94 ...
متن کاملIFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure
We have previously shown that interferon gamma (IFN-γ) induces aberrant CD49b(+) natural killer (NK) cell recruitment by regulating CX3CL1 and eventually provokes foetal loss. In this study, we show that IFN-γ also modulates Ly-49 receptors on NK cells during pregnancy failure. The percentages of Ly-49A(+) and Ly-49G2(+) NK cells in the uteri of the IFN-γ-treated group were significantly lower ...
متن کاملIκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells.
Interferon-γ (IFN-γ) production by natural killer (NK) cells and cytotoxic lymphocytes is a key component of innate and adaptive immune responses. Because inhibitor of κB-ζ (IκBζ), a Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) inducible transcription factor, regulates IFN-γ production in KG-1 cells, we tested IκBζ's role in the classic lymphocyte pathway of IL-12/IL-18-induced IFN-γ...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2008
ISSN: 0741-5400
DOI: 10.1189/jlb.0108046